In 2003, the research groups of Howitz and Sinclair reported that resveratrol extending the lifespan of yeast, worms and fruit flies. In 2006, an Italian research group reported that the supplement extended the lifespan of short-lived fish.

However, the study also showed that there was an increased incidence of mortality among the younger fish. The theory is that the nutrient has a weak toxic activity, which can either stimulate defense mechanisms to extend lifespan or shorten it, probably depending on the overall health of the immune system.


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